![]() ![]() ![]() In fact, attenuation correction is even more important in the case of small-animal imaging as in many micro-SPECT studies, the quantification of the activity in a lesion is more important than the detection of lesions (contrary to clinical imaging). 1– 3 In recent years, it has become clear that attenuation correction should also be considered in small-animal micro-SPECT. Different authors have shown that the application of attenuation correction in clinical SPECT imaging improves diagnostic accuracy. THE NECESSITY OF attenuation correction in clinical single-photon emission computed tomography (SPECT) studies has been extensively studied. When accurate quantification is necessary, a UTE-MR-based attenuation correction should be used. The feasibility of MR-based attenuation correction was shown. Attenuation correction should always be performed for quantification. No attenuation correction yields errors ≥ 15% in the brain scans and ≥ 25% in the body scans. The uniform map yields errors of ≤ 6% in the body scans. It yields nonsignificant differences for the body scans. The UTE-MR-based attenuation correction performed best, with average errors ≤ 8% in the brain scans and ≤ 3% in the body scans. The average difference with the micro-CT-based reconstruction was calculated. The micro-SPECT images were reconstructed without attenuation correction, with micro-CT-based attenuation maps, and with three MR-based attenuation maps: uniform, non-UTE-MR based (air, soft tissue), and UTE-MR based (air, lung, soft tissue, bone). ![]() Different tracers were used: hexamethylpropyleneamine oxime (brain), dimercaptosuccinic acid (kidney), colloids (liver and spleen), and macroaggregated albumin (lung). Micro-SPECT, micro-CT, and MR images of 18 rats were acquired. An ultrashort echo time (UTE) sequence yields signal in bone and lungs. Derivation of the attenuation map from magnetic resonance (MR) images is difficult because bone and lung are invisible in conventional MR images and hence indistinguishable from air. In general, this is done based on micro–computed tomographic (micro-CT) images. All subjects Allied Health Cardiology & Cardiovascular Medicine Dentistry Emergency Medicine & Critical Care Endocrinology & Metabolism Environmental Science General Medicine Geriatrics Infectious Diseases Medico-legal Neurology Nursing Nutrition Obstetrics & Gynecology Oncology Orthopaedics & Sports Medicine Otolaryngology Palliative Medicine & Chronic Care Pediatrics Pharmacology & Toxicology Psychiatry & Psychology Public Health Pulmonary & Respiratory Medicine Radiology Research Methods & Evaluation Rheumatology Surgery Tropical Medicine Veterinary Medicine Cell Biology Clinical Biochemistry Environmental Science Life Sciences Neuroscience Pharmacology & Toxicology Biomedical Engineering Engineering & Computing Environmental Engineering Materials Science Anthropology & Archaeology Communication & Media Studies Criminology & Criminal Justice Cultural Studies Economics & Development Education Environmental Studies Ethnic Studies Family Studies Gender Studies Geography Gerontology & Aging Group Studies History Information Science Interpersonal Violence Language & Linguistics Law Management & Organization Studies Marketing & Hospitality Music Peace Studies & Conflict Resolution Philosophy Politics & International Relations Psychoanalysis Psychology & Counseling Public Administration Regional Studies Religion Research Methods & Evaluation Science & Society Studies Social Work & Social Policy Sociology Special Education Urban Studies & Planning BROWSE JOURNALSĪttenuation correction is necessary for quantification in micro–single-photon emission computed tomography (micro-SPECT). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |